Henry Knowles Beecher (February 4, 19041 â July 25, 19762) was a pioneering American anesthesiologist, medical ethicist, and investigator of the placebo effect at Harvard Medical School. 274(â24)â : 1354-1360, by permission of the Massachusetts Medical Society Fifty years ago, Henry Beecher warned about serious problems with human-subjects research in the United States and exhorted researchers to reform. Henry Knowles Beecher (February 4, 1904  â July 25, 1976 ) was an important figure in the history of anesthesiology and medicine, receiving awards and honors during his career.His 1966 article on unethical medical experimentation in the New England Journal of Medicine was instrumental in the implementation of federal rules on human experimentation and informed consent. With David Janssen, Lin McCarthy, Joe Maross, June Harding. Original article reproduced from the New England Journal of Medicine 1966 ; Vol. Among several seminal moments in the field of research ethics, Henry K. Beecherâs 1966 paper, Ethics and Clinical Research, stands out for its breadth and scope.In what has come to be known in the field as Beecherâs Bombshell, the paper reported on 22 prominent studies that contained serious ethical issues; the impact of the âbombshellâ has been felt throughout the field ever since. Title U.S. Reports: Beecher v. Alabama, 389 U.S. 35 (1967). ... June 16, 1966 N Engl J Med 1966; 274:1354-1360 DOI: 10.1056/NEJM196606162742405. Activate your online access. In that 40 â¦ When he Directed by James Neilson. The ethics of clinical research on human subjects has a rich history that belies its relatively recent development in the mid-twentieth century, marked by publications such as the Nuremberg Code , Henry Beecherâs landmark 1966 paper âEthics and Clinical Researchâ , the Belmont Report , and the Declaration of Helsinki . In 1966, he published 22 examples of unethical research out of a collection of 50 studies that he had read in leading journals at the time (Beecher, 1966). Purchase this article Print Subscriber? 3 Beecher continued to maintain this stance in his famous 1966 article, which included some of the cases that had stimulated the 1959 report, but by 1966 his argument had shifted somewhat. Henry K. Beecher, M.D. Contributor Names Supreme Court of the United States (Author) Dr. Kimble is working as a hired hand on a failing ranch while the local sheriff is looking for a recently escaped murderer.  In his later years, he became fascinated with the region; between 1964 and 1966, Beecher took a leave of absence from Santa Clara University, where he was poet-in-residence, to report on the South and the Civil Rights movement as correspondent for the San Francisco Chronicle and Ramparts magazine. Meanwhile, back in Stafford, a national newspaper publisher offers a $10,000 reward for Kimble's capture. In 1966, Beecherâs widely read article outlined numerous instances in which the health of patients was put in jeopardy in the interests of advancing medical science (Beecher, 1966) and in 1972, the notorious Tuskegee syphilis study was exposed and halted.